Fisetin Benefits, Dosage & Side Effects Supplement Information and Usage Guide

Fisetin is a flavonoid found in fruits and vegetables that supports brain health, reduces inflammation, and promotes healthy aging by acting as an antioxidant.

Fisetin is a natural flavonoid found in fruits like strawberries and apples, known for its antioxidant and anti-aging properties.

It supports cellular health, cognitive function, and may help clear senescent cells to promote longevity.

Fisetin supplements are gaining popularity in longevity circles and are generally considered safe at appropriate dosages.

Other names & forms of Fisetin supplement : flavonol fisetin, senolytic supplement, antioxidant fisetin, neuroprotective fisetin

Benefits

Fisetin is a flavonoid that activates sirtuin pathways and inhibits pro-inflammatory kinases, providing robust antioxidant and senolytic effects.

• Helps support Anti-Aging by clearing senescent cells and reducing oxidative stress at the cellular level.
• May promote Cognitive Health through neuroprotective mechanisms that protect neurons from degeneration.
• Contributes to Heart Health by reducing inflammation in vascular tissues and improving endothelial function.
• Often used to enhance General Health by modulating inflammatory pathways and supporting cellular repair.

Dosage

Appropriate doses of Fisetin supplement are determined by health status and professional guidance:

• Senolytic and brain antioxidant: 100–500 mg/day of Fisetin, often used in cycling protocols.
• Uses: Supports healthy aging, inflammation reduction, and cellular cleanup.
• Forms: Capsules or powders, sometimes liposomal.
• Recommendation: Take with fat-containing meals; short-term intensive dosing may be used in senolytic stacks.

Side Effects

Fisetin is a flavonoid with senolytic properties, but some users report mild effects as cellular pathways adjust. Watch for:

• Possible headache or dizziness during initial days
• Mild gastrointestinal upset—nausea or cramps
• Occasional skin rash or itching—in hypersensitive individuals
• Temporary mild fatigue or drowsiness
• Rare changes in sleep patterns if taken late

Interactions

Possible interactions include:

• Anticoagulant therapies: Fisetin’s platelet effects may add to warfarin or Garlic, monitor INR.

Precautions

Before supplementing with Fisetin, ensure none of the following apply to you. If they do, consult your healthcare provider:

• Individuals on chemotherapy or radiation therapy: May interfere with senolytic mechanisms; discuss with oncologist
• People with hormone-sensitive conditions: Limited data; use cautiously
• Pregnant or breastfeeding women: Safety not established; avoid supplements
• Those with liver or kidney impairment: Monitor function if used long term
• Patients scheduled for surgery: Discontinue one week prior—possible anesthesia interactions

This article was originally published on Stackbb.com, your trusted source for science-based supplement guides.