Butterbur

Possible Benefits

Butterbur contains petasins, which are thought to reduce inflammation and prevent spasms in blood vessels and smooth muscle tissues.

• Helps reduce the frequency and severity of migraines, supporting Pain Relief for headache disorders.
• May support Lung Health by reducing histamine release and alleviating allergy symptoms.
• Used to promote General Health through its anti-inflammatory effects.

Side Effects

Butterbur can help ease migraine pain and support respiratory health, but some users notice mild effects as their system adapts. Keep an eye out for:

• Possible mild gastrointestinal upset, nausea, stomach cramps, or diarrhea, especially with PA-containing extracts
• Occasional headache or fatigue during initial use
• Mild dizziness or lightheadedness in sensitive individuals
• Rare allergic skin reactions, rash or itching, in those sensitive to Asteraceae family plants
• Temporary mild changes in liver enzymes with high-dose or long-term use; use PA-free formulations to minimize risk

Interactions

Possible interactions include:

• Antihistamines and decongestants: Butterbur’s petasin may potentiate effects of loratadine or pseudoephedrine, increasing drowsiness or dry mouth, use with caution.
• NSAIDs and anti-inflammatories: Combined anti-inflammatory action with ibuprofen or Turmeric & Curcumin may heighten GI irritation, monitor for discomfort.
• Liver-metabolized drugs: Butterbur may alter CYP450 activity, affecting medications like statins or CoQ10; consider liver function monitoring.
• Topical migraine treatments: When used with ergotamine creams, petasin may enhance vasoconstriction; avoid simultaneous topical applications.

Precautions

Before incorporating Butterbur into your routine, confirm none of the following apply to you. If they do, consult your healthcare provider:

• Individuals with liver disease: Use only PA-free extracts to reduce hepatotoxic risk; monitor liver function if used long term
• People with ragweed or pollen allergies: High risk of cross-reactive allergic reactions; avoid if sensitive
• Those on blood-thinning medications: Potential to increase bleeding risk; monitor clotting parameters
• Pregnant or breastfeeding women: Limited safety data; best to avoid unless under professional guidance
• Patients scheduled for surgery: Discontinue at least two weeks prior, possible interactions with anesthesia and bleeding risk

Studies