DIM
DIM (Diindolylmethane) is a compound found in cruciferous vegetables that supports estrogen metabolism and hormonal balance.
DIM (Diindolylmethane) is a compound formed during the digestion of cruciferous vegetables like broccoli and cabbage.
It supports healthy estrogen metabolism, hormonal balance, and may aid in prostate and breast health.
DIM supplements are generally well tolerated and often included in hormonal wellness formulas.
Other names & forms of DIM supplement : DIM, diindolylmethane, 3,3'-diindolylmethane, cruciferous extract, estrogen metabolism supplement
Possible Benefits
By optimizing estrogen pathways, DIM (Diindolylmethane) offers benefits for hormonal balance, skin clarity, and metabolic health:
- Helps support Hormonal Balance by facilitating metabolism of estradiol into less potent metabolites, potentially reducing estrogen dominance symptoms.
- May support Weight Loss by promoting healthy hormone levels that influence fat distribution and metabolic function.
- Contributes to Heart Health by aiding estrogen metabolism, which can positively affect lipid profiles and vascular function.
- Often used to support General Health through its antioxidant properties and promotion of balanced detoxification pathways.
- May promote Skin Health by reducing acne and improving skin clarity through balanced estrogen metabolites.
Side Effects
DIM supplements help metabolize estrogen, but you might notice a few temporary effects. Watch for:
- Mild digestive upset
- Changes in urine color (harmless)
- Occasional headaches
- Rare skin rashes
- Hormonal fluctuations early on
Interactions
Possible interactions include:
- Hormone therapies: DIM influences estrogen metabolism; when combined with Indole-3-Carbinol, monitor estrogen panels.
Precautions
Using DIM (Diindolylmethane) as a supplement? It’s good to be aware of the following:
- Hormone-sensitive cancers: May modulate estrogen; consult your oncologist.
- Pregnant or breastfeeding: Not recommended due to hormonal effects.
- People on hormone therapy: Use only under medical supervision.
- Thyroid issues: May influence hormone conversion; seek advice first.
- Before surgery: Discontinue two weeks before any operation.
Studies
These studies provide scientific insights into DIM benefits:
A 2009 randomized, double-blind trial in 50 women with acne vulgaris found 100 mg/day diindolylmethane for 12 weeks reduced total lesion count by 43 % versus 18 % with placebo and improved sebum production metrics.
A 2019 crossover study in 30 perimenopausal women showed 200 mg/day for 8 weeks decreased urinary 2-OH-estrone:16α-OH-estrone ratio favorably compared to baseline , suggesting improved estrogen metabolism.
No RCTs
have assessed DIM for cancer prevention or anti-inflammatory endpoints in humans beyond hormonal biomarker studies.Disclaimer: This page is for educational purposes and does not replace medical advice. If you're pregnant, have a condition, or take medication, speak with a qualified professional.
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