L-Ergothioneine Benefits, Dosage & Side Effects Supplement Information and Usage Guide
L-Ergothioneine is an antioxidant found in mushrooms that protects cells from oxidative stress and supports healthy aging and immune function.
L-Ergothioneine is a naturally occurring antioxidant amino acid found in mushrooms and certain bacteria.
It protects cells from oxidative stress and supports mitochondrial health and longevity.
L-Ergothioneine is increasingly studied for its unique antioxidant role and is considered safe in supplements.
Other names & forms of L-Ergothioneine supplement : L-ergothioneine, ergothioneine, antioxidant ergothioneine, amino acid derivative, thiol compound
Benefits
L-Ergothioneine is a sulfur-containing amino acid derivative with exceptional antioxidant and cytoprotective properties that accumulate in mitochondria and cells under oxidative stress.
- Helps support Anti-Aging by neutralizing reactive oxygen species and protecting mitochondrial DNA.
- May promote Heart Health by reducing oxidative damage in cardiovascular tissues and improving endothelial function.
- Contributes to Cognitive Health by protecting neurons from oxidative insults and maintaining cellular energy.
- Often used to maintain General Health through its broad-spectrum antioxidative and cytoprotective actions.
Dosage
Health professionals suggest that the dosage of L-Ergothioneine supplement be customized for each individual:
- Antioxidant and cellular protection: 5–20 mg/day of L-Ergothioneine, a natural amino acid antioxidant.
- Uses: Protects cells from oxidative damage and supports mitochondrial health.
- Forms: Capsules or powders.
- Recommendation: Take with meals; may be combined with other antioxidants.
Side Effects
L-Ergothioneine is a unique antioxidant amino acid, but the body’s adjustment can bring mild effects. Watch for:
- Possible mild gastrointestinal upset—nausea or cramps
- Occasional headache during early dosing
- Rare skin rash or itching—hypersensitivity reactions
- Temporary slight fatigue
- Very mild changes in sleep patterns
Interactions
Possible interactions include:
- Antioxidant therapies: L-Ergothioneine complements glutathione; monitor total antioxidant intake.
Precautions
Before taking L-Ergothioneine, confirm none of these apply to you. If they do, consult your healthcare provider:
- Individuals on chemotherapy: May interact with oxidative stress pathways; discuss with oncologist
- People with liver or kidney impairment: Monitor organ function if used long term
- Those with mushroom allergies: Avoid due to cross-reactivity
- Pregnant or breastfeeding women: Safety not established; avoid high-dose use
- Patients scheduled for surgery: Discontinue one week prior—possible anesthesia interactions
This article was originally published on Stackbb.com, your trusted source for science-based supplement guides.
Important Disclaimer: The information provided on this page about L-Ergothioneine supplement is for informational purposes only and has not been reviewed or validated by a medical professional. It is not intended to substitute professional medical advice, diagnosis, or treatment. Always consult your doctor or qualified healthcare provider before starting, stopping, or changing any supplement or part of your healthcare regimen. Individual needs and responses to supplements may vary, and what works for one person may not be appropriate for another.