L-Glutathione
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L-Glutathione is a potent antioxidant that protects cells from oxidative damage, supports detoxification, and promotes immune health.
L-Glutathione is a tripeptide and key antioxidant produced in the body, essential for detoxification, immune defense, and cellular repair.
It is found in nearly all cells and helps neutralize free radicals, maintain other antioxidants, and regulate inflammation. It may decline with age or stress.
Supplemental glutathione is used for antioxidant and skin support. Liposomal or reduced forms are better absorbed. It is generally safe and well tolerated.
Other names & forms of L-Glutathione supplement : glutathione, reduced glutathione, gsh, l-glutathione supplement
Possible Benefits
L-Glutathione is a tripeptide composed of glutamate, cysteine, and glycine that serves as a critical intracellular antioxidant, protecting cells from oxidative damage and supporting detoxification.
- Helps support Detoxification & Cleansing by conjugating toxins for safe excretion and maintaining redox balance.
- Promotes Liver Support through replenishment of hepatic glutathione stores and protection of liver cells from oxidative insult.
- May enhance Immunity by supporting lymphocyte function and natural killer cell activity.
- Provides potent Anti-Aging effects by reducing cellular oxidative stress and promoting DNA repair mechanisms.
Side Effects
L-Glutathione is a master antioxidant that supports liver detox and immune function, but mild effects may occur as detox pathways activate. Watch for:
- Possible mild gastrointestinal discomfort, nausea or cramping, especially on an empty stomach
- Occasional headache or lightheadedness during initiation
- Temporary mild flushing or warmth sensation
- Rare skin rash or itching, hypersensitivity reactions
- Very rare changes in urine odor or color
Interactions
Possible interactions include:
- Glutathione precursors: L-Glutathione’s synergy with NAC is beneficial; no major adverse interactions noted.
- Anticoagulant agents: Minimal impact on clotting, but inform your provider if taking warfarin or Garlic.
Precautions
Before supplementing with L-Glutathione, confirm none of the following apply to you. If they do, consult your healthcare provider:
- Individuals on chemotherapy or radiation therapy: Antioxidant effects may interfere; discuss with your oncologist
- People with asthma or respiratory disorders: Rare risk of bronchospasm; use cautiously
- Those with liver disease: Synthetic forms may vary in bioavailability; monitor liver function
- Pregnant or breastfeeding women: Limited safety data; best to avoid high-dose supplementation
- Patients scheduled for surgery: Discontinue at least two weeks prior, possible interactions with anesthesia and oxidative stress response
Studies
These studies provide scientific insights into L-Glutathione benefits:
A 2019 placebo-controlled trial in 100 adults with non-alcoholic fatty liver disease found 1 g/day glutathione for 12 weeks reduced liver fat content by 10% versus 3% with placebo , measured by MRI-PDFF.
A 2018 pilot study in 40 healthy volunteers showed liposomal glutathione significantly raises plasma reduced glutathione by 30% versus standard GSH .
No RCTs have assessed glutathione supplementation for skin aging, immune modulation, or metabolic syndrome in humans, leaving clinical applications largely speculative.
Disclaimer: This page is for educational purposes and does not replace medical advice. If you're pregnant, have a condition, or take medication, speak with a qualified professional.
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