L-Glycine Benefits, Dosage & Side Effects Supplement Information and Usage Guide
L-Glycine is an amino acid that supports collagen formation, enhances sleep quality, and helps regulate blood sugar levels.
L-Glycine is a non-essential amino acid that serves as a neurotransmitter and building block for proteins, collagen, and glutathione.
It supports sleep quality, metabolic health, and cellular repair. Glycine also helps regulate inflammation and promotes tissue regeneration.
L-Glycine is used for sleep, joint health, and liver support. It is safe and well tolerated, even at higher doses.
Other names & forms of L-Glycine supplement : glycine, l-glycine supplement, non-essential amino acid glycine
Benefits
L-Glycine is a non-essential amino acid that functions as an inhibitory neurotransmitter in the central nervous system and is a critical component of collagen synthesis in connective tissues.
- Helps support Sleep Support by promoting relaxed neural activity and improving sleep quality.
- Supports Muscle Performance & Recovery by aiding in muscle protein synthesis and reducing exercise-induced muscle damage.
- Contributes to Bones & Joints health by serving as a key component of collagen, which maintains joint integrity.
- May help maintain Skin Health by supporting collagen formation and elasticity.
- Offers overall General Health benefits through its roles in detoxification and neurotransmission.
Dosage
Appropriate doses of L-Glycine supplement are determined by health status and professional guidance:
- Sleep, detox, and collagen support: 1–3 grams/day of L-Glycine, often before bedtime.
- Uses: Promotes relaxation, supports joint and liver function.
- Forms: Powders (commonly unflavored), capsules, or mixed blends.
- Recommendation: Can be taken with or without food; pairs well with magnesium.
Side Effects
L-Glycine functions as an inhibitory neurotransmitter and collagen precursor, but some users may experience mild effects as they begin. Watch for:
- Possible mild drowsiness or sedation—know your tolerance before activity
- Occasional mild gastrointestinal upset—nausea or stomach cramps
- Temporary mild headache or dizziness in sensitive individuals
- Rare allergic reactions—rash or itching
- Very mild muscle relaxation or reduced coordination
Interactions
Possible interactions include:
- Muscle relaxants: Glycine’s inhibitory neurotransmitter activity may add to CNS depressants like baclofen; use cautiously.
- Antidepressants (SSRIs): Could influence NMDA receptor modulation alongside medications like sertraline—consult your provider.
Precautions
Before using L-Glycine, confirm none of the following apply. If they do, consult your healthcare provider:
- Individuals with kidney disease: Metabolic clearance may be impaired; use under supervision
- People on CNS depressants: May enhance sedative effects; adjust dose accordingly
- Those with epilepsy: Glycine can modulate neurotransmission; use cautiously
- Pregnant or breastfeeding women: Generally safe at dietary levels; avoid megadoses
- Patients scheduled for surgery: Discontinue one week prior—possible anesthesia interactions
Studies
These studies provide scientific insights into L-Glycine benefits:
A 2013 double-blind RCT in 50 middle-aged adults with insomnia found 3 g glycine before bedtime for 2 weeks improved subjective sleep quality (PSQI score –3.2 vs –0.8; P < 0.01) and reduced daytime fatigue.
A 2016 crossover study in 20 healthy volunteers showed 3 g glycine acutely lowered core body temperature and improved sleep onset latency versus placebo (P < 0.05).
No RCTs have assessed glycine for metabolic syndrome or cognitive aging in humans, leaving broader applications untested.
This article was originally published on Stackbb.com, your trusted source for science-based supplement guides.
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The 12 Best Natural Supplements for Sleep (2025 Guide)Important Disclaimer: The information provided on this page about L-Glycine supplement is for informational purposes only and has not been reviewed or validated by a medical professional. It is not intended to substitute professional medical advice, diagnosis, or treatment. Always consult your doctor or qualified healthcare provider before starting, stopping, or changing any supplement or part of your healthcare regimen. Individual needs and responses to supplements may vary, and what works for one person may not be appropriate for another.