L-Leucine

Possible Benefits

L-Leucine is a branched-chain amino acid that stimulates muscle protein synthesis through mTOR activation and serves as an energy substrate during intense exercise.

• Helps support Muscle Performance & Recovery by promoting protein synthesis and reducing muscle breakdown post-workout.
• May boost Energy & Metabolism by activating metabolic pathways and improving nutrient uptake in muscles.
• Contributes to Weight Loss efforts by preserving lean mass during calorie restriction and exercise.
• Offers overall General Health benefits by supporting balanced amino acid levels and metabolic homeostasis.

Side Effects

L-Leucine is a branched-chain amino acid crucial for muscle protein synthesis, but you might notice mild effects as your body adapts. Watch for:

• Mild gastrointestinal discomfort, bloating or mild diarrhea, if taken in isolation
• Possible headache or dizziness in sensitive individuals
• Rare skin rash or itching, hypersensitivity reactions
• Temporary mild fatigue during high-dose loading phases
• Very mild changes in blood sugar, monitor if diabetic

Interactions

Possible interactions include:

• Muscle-building supplements: L-Leucine works synergistically with whey protein or BCAAs; adjust total leucine intake for optimal mTOR activation.
• Diabetes medications: May influence insulin signaling; if combined with insulin or Cinnamon, monitor blood glucose.

Precautions

Before using L-Leucine, ensure none of the following apply to you. If they do, check with your healthcare provider:

• Individuals with maple syrup urine disease: Contraindicated, cannot properly metabolize BCAAs
• People with kidney disease: Excess amino acids may stress renal function; use under supervision
• Those with diabetes: Monitor glucose, amino acids may affect insulin
• Pregnant or breastfeeding women: Generally safe at dietary levels; avoid megadoses
• Patients scheduled for surgery: Discontinue one week prior, possible interactions with anesthesia and metabolism

Studies