NR

Possible Benefits

NR (Nicotinamide Riboside) elevates NAD⁺ levels to support cellular repair, mitochondrial health, and metabolic function.

• Helps maintain Energy & Metabolism by boosting NAD⁺ availability, improving mitochondrial efficiency.
• May promote Anti-Aging via sirtuin activation that enhances DNA repair and cellular resilience.
• Contributes to Heart Health by supporting cardiomyocyte energy production and reducing oxidative stress.
• Often used to support Cognitive Health by protecting neurons from metabolic decline and oxidative damage.

Side Effects

NR (Nicotinamide Riboside) supports mitochondrial function by raising NAD+, yet introductory use can bring mild effects. Watch for:

• Occasional mild nausea or stomach upset
• Possible headache during initial days of use
• Temporary slight insomnia if taken late
• Rare skin rash or itching, hypersensitivity reactions
• Very mild fatigue as cellular pathways adapt

Interactions

Possible interactions include:

• Niacin therapies: NR’s NAD+ precursors may complement niacin; balance dosing to avoid flushing.

Precautions

Before using NR, confirm none of the following apply to you. If they do, consult your healthcare provider:

• Individuals undergoing chemotherapy: May alter NAD+ metabolism; discuss with your oncologist
• People with liver disease: Monitor liver enzymes with long-term use
• Those with hypotension: May cause mild blood pressure changes; monitor regularly
• Pregnant or breastfeeding women: Safety not established; avoid supplements
• Patients scheduled for surgery: Discontinue at least one week prior, possible anesthesia interactions

Studies