Phosphatidylserine

Possible Benefits

As a phospholipid component of neuronal membranes, Phosphatidylserine supports cell signaling and helps modulate cortisol release under stress.

• Helps support Cognitive Health by enhancing memory recall and attention through improved synaptic function.
• May aid Nervous System & Stress Relief by reducing cortisol levels and promoting a calmer response to daily stressors.
• Contributes to Anti-Aging by protecting neuronal membranes from oxidative damage and preserving brain volume.
• Often used to promote General Health by supporting healthy adrenal function and mood balance.

Side Effects

Phosphatidylserine supports cognitive function via neurotransmitter balance, but initial use can bring mild effects. Watch for:

• Occasional gastrointestinal upset, nausea or diarrhea
• Possible headache or insomnia if taken late
• Rare skin rash or itching, hypersensitivity reactions
• Temporary mild fatigue during adaptation
• Very mild changes in mood or irritability

Interactions

Possible interactions include:

• Choline therapies: Phosphatidylserine may complement phosphatidylcholine; adjust to balance choline sources.
• Antidepressants: GABAergic effects, monitor if combined with SSRIs or anxiolytics.

Precautions

Before adding Phosphatidylserine, ensure none of the following apply. If they do, consult your healthcare provider:

• Individuals on blood-thinning medications: Possible additive effects; monitor clotting
• People with bipolar disorder: May affect mood; use under psychiatric guidance
• Those with soy or egg allergy: Common sources; choose allergen-free formulas
• Pregnant or breastfeeding women: Limited safety data; stick to dietary sources unless advised
• Patients scheduled for surgery: Discontinue one week prior, possible anesthesia interactions

Studies