Phosphatidylserine Benefits, Dosage & Side Effects Supplement Information and Usage Guide
Phosphatidylserine is a phospholipid that supports cognitive function, memory, and stress reduction by promoting healthy brain cell membranes.
Phosphatidylserine is a phospholipid found in high concentrations in the brain, where it supports cognitive function and memory.
It helps maintain healthy cell membranes, communication between neurons, and stress response regulation.
Phosphatidylserine supplements are well tolerated and often used for age-related cognitive support.
Other names & forms of Phosphatidylserine supplement : PS, brain phospholipid, cognitive support phosphatidylserine, soy-derived phosphatidylserine
Benefits
As a phospholipid component of neuronal membranes, Phosphatidylserine supports cell signaling and helps modulate cortisol release under stress.
- Helps support Cognitive Health by enhancing memory recall and attention through improved synaptic function.
- May aid Nervous System & Stress Relief by reducing cortisol levels and promoting a calmer response to daily stressors.
- Contributes to Anti-Aging by protecting neuronal membranes from oxidative damage and preserving brain volume.
- Often used to promote General Health by supporting healthy adrenal function and mood balance.
Dosage
Phosphatidylserine supplement is used in varying doses tailored to individual health situations:
- Memory and stress support: 100–300 mg/day of Phosphatidylserine (PS), often derived from soy or sunflower.
- Uses: Cognitive enhancement, stress reduction, and cortisol modulation.
- Forms: Capsules or softgels.
- Recommendation: Take with meals; evening use may improve sleep quality in some people.
Side Effects
Phosphatidylserine supports cognitive function via neurotransmitter balance, but initial use can bring mild effects. Watch for:
- Occasional gastrointestinal upset—nausea or diarrhea
- Possible headache or insomnia if taken late
- Rare skin rash or itching—hypersensitivity reactions
- Temporary mild fatigue during adaptation
- Very mild changes in mood or irritability
Interactions
Possible interactions include:
- Choline therapies: Phosphatidylserine may complement phosphatidylcholine; adjust to balance choline sources.
- Antidepressants: GABAergic effects—monitor if combined with SSRIs or anxiolytics.
Precautions
Before adding Phosphatidylserine, ensure none of the following apply. If they do, consult your healthcare provider:
- Individuals on blood-thinning medications: Possible additive effects; monitor clotting
- People with bipolar disorder: May affect mood; use under psychiatric guidance
- Those with soy or egg allergy: Common sources; choose allergen-free formulas
- Pregnant or breastfeeding women: Limited safety data; stick to dietary sources unless advised
- Patients scheduled for surgery: Discontinue one week prior—possible anesthesia interactions
Studies
These studies provide scientific insights into Phosphatidylserine benefits:
A 2002 randomized, double-blind trial in 63 elderly subjects with age-associated memory impairment found 300 mg/day phosphatidylserine for 12 weeks improved recall and learning tests by 15% versus 5% with placebo (P < 0.05).
A 2005 crossover study in 20 healthy men showed 400 mg/day phosphatidylserine attenuated cortisol response to acute exercise by 30% versus placebo (P < 0.01), suggesting stress-modulating effects.
This article was originally published on Stackbb.com, your trusted source for science-based supplement guides.
Important Disclaimer: The information provided on this page about Phosphatidylserine supplement is for informational purposes only and has not been reviewed or validated by a medical professional. It is not intended to substitute professional medical advice, diagnosis, or treatment. Always consult your doctor or qualified healthcare provider before starting, stopping, or changing any supplement or part of your healthcare regimen. Individual needs and responses to supplements may vary, and what works for one person may not be appropriate for another.