Progesterone Benefits, Dosage & Side Effects Supplement Information and Usage Guide
Progesterone is a hormone that supports reproductive health, regulates the menstrual cycle, and is used in hormone replacement therapy.
Progesterone is a hormone essential for regulating menstruation, pregnancy, and hormonal balance.
Supplemental progesterone supports reproductive health, mood, and may alleviate menopause-related symptoms.
Progesterone should be used under medical supervision, especially in bioidentical hormone replacement therapy (BHRT).
Other names & forms of Progesterone supplement : natural progesterone, bioidentical progesterone, hormone support supplement
Benefits
Progesterone cream supplies bioidentical hormones that bind to progesterone receptors, helping to balance estrogen levels and support menstrual regularity.
- Helps support Hormonal Balance by normalizing progesterone-to-estrogen ratios, reducing symptoms like mood swings and bloating.
- May alleviate Women's Health issues such as PMS and perimenopausal discomfort through targeted hormone replacement.
- Contributes to Skin Health by maintaining collagen synthesis and preventing dryness associated with hormonal fluctuations.
- Often used to enhance General Health by supporting bone density and reducing anxiety during low-progesterone phases.
Dosage
Health professionals suggest that the dosage of Progesterone supplement be customized for each individual:
- Hormonal support: 20–40 mg/day of topical Progesterone cream or 100–200 mg/day in oral form (prescription strength).
- Uses: Menopause, PMS, and hormone regulation.
- Forms: Cream, capsules, or lozenges.
- Recommendation: Best used under healthcare supervision; dosage may vary by phase of menstrual cycle.
Side Effects
Progesterone supplements support hormonal balance, but some people may experience mild effects at first. Watch for:
- Mild fatigue or drowsiness
- Breast tenderness
- Occasional headaches
- Rare nausea
- Minor mood fluctuations
Interactions
Possible interactions include:
- Progesterone and estrogen therapies: Progesterone supplements interact with HRT regimens; monitor hormone levels.
Precautions
Progesterone supplementation should be approached carefully, especially in the following cases:
- Hormone-sensitive cancers: Strictly contraindicated.
- Pregnancy: Use only under close medical supervision.
- History of thrombosis or clotting disorders: Increased risk; avoid use.
- Liver impairment: Requires monitoring and medical oversight.
- Before surgery: Discontinue at least two weeks prior.
Studies
These studies provide scientific insights into Progesterone benefits:
A 2013 double-blind RCT in women with a sonographic short cervix (≤25 mm) showed 200 mg/day vaginal progesterone gel from 24–34 weeks reduced preterm birth before 34 weeks (14 % vs 27 % placebo; RR 0.52; P = 0.023).
A 2014 Cochrane review of 42 RCTs concluded that progesterone supplementation for threatened miscarriage in early pregnancy increases live birth rates by 17 % (RR 1.17; 95 % CI: 1.05–1.30).
A 2005 double-blind RCT in 60 menopausal women found 300 mg/day oral micronized progesterone for 12 weeks reduced hot-flash frequency by 45 % versus 20 % with placebo (P < 0.01).
A 2000 randomized trial in IVF patients reported that adjunctive intramuscular progesterone (100 mg/day) for luteal support increased clinical pregnancy rates from 28 % to 38 % versus no supplement (P = 0.04).
This article was originally published on Stackbb.com, your trusted source for science-based supplement guides.
Important Disclaimer: The information provided on this page about Progesterone supplement is for informational purposes only and has not been reviewed or validated by a medical professional. It is not intended to substitute professional medical advice, diagnosis, or treatment. Always consult your doctor or qualified healthcare provider before starting, stopping, or changing any supplement or part of your healthcare regimen. Individual needs and responses to supplements may vary, and what works for one person may not be appropriate for another.