Spermidine
Spermidine is a polyamine that supports cellular regeneration, longevity, and autophagy, the body's natural process of cleaning out damaged cells.
Spermidine is a polyamine compound found in foods like wheat germ and aged cheese. It is associated with cellular renewal and longevity.
It supports autophagy, the body’s process of clearing out damaged cells, and has been studied for its potential anti-aging and brain health benefits.
Spermidine is used for healthy aging and cognitive support. It is typically well tolerated, but more human research is needed for long-term effects.
Other names & forms of Spermidine supplement : polyamine compound, wheat germ extract, spermidine supplement
Possible Benefits
Spermidine is a polyamine that promotes autophagy, supports mitochondrial function, and helps maintain cellular homeostasis by regulating cell growth and longevity pathways.
- Helps support Anti-Aging by inducing autophagy and clearing damaged proteins within cells.
- May contribute to Heart Health by improving mitochondrial efficiency and reducing cardiac cell stress.
- Supports Cognitive Health by promoting neuronal autophagy and synaptic maintenance.
- Offers overall General Health benefits through enhanced cellular regeneration and metabolic regulation.
Side Effects
Spermidine is researched for autophagy and cellular renewal, but mild effects can occur as your cells adapt. Watch for:
- Occasional gastrointestinal upset, nausea or mild cramps, especially when taken on an empty stomach
- Possible headache or dizziness during initial use
- Mild transient fatigue as cellular processes ramp up
- Rare skin rash or itching, hypersensitivity reactions
- Temporary mild changes in sleep patterns, monitor if sensitive
Interactions
Possible interactions include:
- Polyamine-targeting drugs: Spermidine’s autophagy-promoting effects may complement mTOR inhibitors; consult your oncologist if on rapamycin.
- Antioxidant supplements: Combined with NAC or glutathione, allows synergy in cellular protection, monitor overall antioxidant status.
Precautions
Before supplementing with Spermidine, confirm none of the following apply to you. If they do, consult your healthcare provider:
- Individuals on immunosuppressive therapy: May modulate autophagy; use under supervision
- People with sleep disorders: Monitor timing, may affect sleep if taken late
- Pregnant or breastfeeding women: Insufficient safety data; best to avoid high-dose use
- Those with nutritional deficiencies: Ensure balanced diet, may chelate nutrients
- Patients scheduled for surgery: Discontinue at least two weeks prior, possible interactions with anesthesia and cell turnover
Disclaimer: This page is for educational purposes and does not replace medical advice. If you're pregnant, have a condition, or take medication, speak with a qualified professional.
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