L-Tryptophan

Possible Benefits

L-Tryptophan is an essential amino acid that acts as a precursor to serotonin and melatonin, regulating mood, sleep, and immune function through its influence on neurotransmitter pathways.

• Helps support Nervous System & Stress Relief by increasing serotonin production and promoting emotional balance.
• May improve Sleep Support by boosting melatonin synthesis and enhancing sleep quality.
• Contributes to General Health by supporting immune function and reducing inflammation.

Side Effects

L-Tryptophan supports serotonin production and sleep, yet initial use can produce mild effects. Watch for:

• Temporary mild drowsiness, avoid driving until you know your response
• Possible headache or nausea during early dosing
• Occasional mild gastrointestinal upset, cramps or bloating
• Rare skin rash or itching in sensitive users
• Very mild muscle relaxation or heaviness

Interactions

Possible interactions include:

• Sedative and anxiolytic medications: L-Tryptophan’s serotonin precursor role may augment SSRIs or benzodiazepines; monitor for excessive sedation or serotonin effects.
• Carbidopa/Levodopa: May compete for transport across the blood-brain barrier; space dosing to avoid efficacy reduction.

Precautions

Before adding L-Tryptophan, ensure none of the following apply. If they do, consult your healthcare provider:

• Individuals on SSRIs or other serotonergic drugs: Risk of serotonin syndrome; avoid or use under supervision
• People with eosinophilia-myalgia syndrome history: Avoid, past contamination issues warrant caution
• Those with liver or kidney disease: Clearance may be reduced; monitor function
• Pregnant or breastfeeding women: Limited data; best to avoid high supplemental doses
• Patients scheduled for surgery: Discontinue one week prior, possible interactions with anesthesia and serotonin regulation

Studies