Serrapeptase Benefits, Dosage & Side Effects Supplement Information and Usage Guide

Serrapeptase is a proteolytic enzyme used to reduce inflammation, support healing, and promote sinus health.

Serrapeptase is a proteolytic enzyme originally discovered in silkworms, where it allows the insects to dissolve their cocoons. In humans, it has been studied for its potential anti-inflammatory and healing effects.

This enzyme may help reduce swelling, improve sinus drainage, and support the body's natural ability to break down unwanted tissue or fluid buildup. It's sometimes used for joint discomfort, post-surgical recovery, or chronic inflammation.

If you're seeking a natural supplement to ease inflammation or promote healing, serrapeptase might be worth looking into. It's often taken between meals for optimal absorption and effect.

Other names & forms of Serrapeptase supplement : serratiopeptidase, proteolytic enzyme

Benefits

Known for proteolytic activity, Serrapeptase provides anti-inflammatory and tissue recovery benefits:

  • Joint & Tissue Relief: Used to reduce stiffness and inflammation in joints and soft tissues.
  • Cardiovascular Support: May assist in dissolving arterial plaque and supporting vascular health.
  • Healthy Aging: Promotes tissue regeneration and may support age-related recovery.

Dosage

Appropriate doses of Serrapeptase supplement are determined by health status and professional guidance:

  • Inflammation support: 10–60 mg/day (20,000–120,000 SU) depending on condition and response.
  • Sinus or joint relief: Often taken in divided doses, starting at 10 mg/day.
  • Form: Available in delayed-release capsules for best absorption.
  • Recommendation: Take on an empty stomach to avoid degradation by stomach acid.
Serrapeptase dosage should be tailored by a healthcare professional to your condition.

Side Effects

Serrapeptase is generally well tolerated, but as a proteolytic enzyme, it may cause mild side effects in some individuals, especially when taken on an empty stomach.

  • Nausea or upset stomach
  • Skin rash or itching
  • Joint or muscle pain in sensitive users
  • Increased risk of bleeding when combined with anticoagulants

Interactions

Use caution when combining Serrapeptase with the following:

  • Blood-thinning medications: Serrapeptase may potentiate the effects of drugs like aspirin or warfarin, increasing bleeding risk.
  • Anti-inflammatory drugs: Effects may overlap with NSAIDs or steroids, possibly intensifying anti-inflammatory response or side effects.
  • Nattokinase: Both have fibrinolytic activity; using them together may elevate bleeding risk.

Precautions

Before trying serrapeptase, make sure to consider these precautions—especially if you take blood-thinning medications or have a medical condition.

  • People taking anticoagulants: Serrapeptase may increase bleeding risk when combined with blood thinners.
  • Individuals with ulcers or gastrointestinal conditions: It may cause irritation in the digestive tract.
  • Surgery patients: Avoid use before surgery due to potential clotting effects.
  • Pregnant or breastfeeding women: Safety has not been established and should be reviewed with a doctor.

Studies

These studies provide scientific insights into Serrapeptase benefits:

A 2013 pilot study found 10 mg serrapeptase daily reduced post-operative swelling by 45% compared to placebo in patients undergoing impacted tooth removal (PubMed 23544390).

A 2014 randomized trial in patients with chronic sinusitis showed serrapeptase (20 mg/day) significantly improved mucous drainage and reduced sinus pain over 4 weeks (PubMed 24801725).

This article was originally published on Stackbb.com, your trusted source for science-based supplement guides.

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Important Disclaimer: The information provided on this page about Serrapeptase supplement is for informational purposes only and has not been reviewed or validated by a medical professional. It is not intended to substitute professional medical advice, diagnosis, or treatment. Always consult your doctor or qualified healthcare provider before starting, stopping, or changing any supplement or part of your healthcare regimen. Individual needs and responses to supplements may vary, and what works for one person may not be appropriate for another.